basic FUNCTION
| playing a critical role in transcriptional regulation, cell cycle progression, and developmental events |
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histodeacetylase, repressor of MEF2 mediated transcription, acting as a signal-responsive suppressor of the transcriptional program governing cardiac hypertrophy and heart failure |
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in addition to its roles in heart development and in T cell functions, HDAC9 has a role in limb patterning by suppression of the sonic hedgehog signaling pathway |
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chromatin remodeling with nucleocytoplasmic translocation of HDAC9 regulates activity-dependent gene expression and dendritic growth in developing cortical neurons |
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regulates a wide variety of normal and abnormal physiological functions, including cardiac growth, T-regulatory cell function, neuronal disorders, muscle differentiation, development, and cancer |
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positive role for HDAC9 in gamma-globin gene regulation |
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function of HDAC9 and HDAC10 in the homologous recombination process |
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negative regulator of cardiomyocyte hypertrophy |
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critical regulatory role of HDAC9 in adipogenic differentiation, independent of its deacetylase activity |
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constitutively a nuclear protein in preadipocytes, and down-regulation of HDAC9 protein within the cell nucleus parallels adipogenic differentiation |
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inhibits adipogenesis at least in part by inhibiting transcriptional processes independently of its HDAC enzymatic activity |
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plays a key role in the development and differentiation of many types of cells, including regulatory T cells |
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acts as an epigenetic switch in effector T cell-mediated systemic autoimmunity |