basic FUNCTION
| initiating biosynthesis of chondroitin and heparan sulfate, heparin and dermatan sulfate |
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transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate |
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is capable of initiating the biosynthesis of glycosaminoglycan chains in proteoglycans |
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XYLT1, XYLT2 are xylosyltransferases with similar but not identical properties, pointing to their potential role in modulating the cellular proteoglycan pool |
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very likely assumes a crucial regulatory role in the biosynthesis of proteoglycans (PGs) |
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XYLT1, XYLT2 catalyze the rate-limiting step in proteoglycan biosynthesis |
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cells of the lens, retina, heart muscle, inner ear, and bone are dependent on XYLT2 for proteoglycan assembly |