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FLASH GENE
Symbol DUSP11 contributors: - updated : 05-05-2006
HGNC name dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
HGNC id 3066
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1639 - 377 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage epidermoid and myeloblastic cell lineages
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved motif at the catalytic site
  • two stretches of arginine-rich sequence
  • a proline-rich region
  • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text colocolizing in nuclear speckles with the splicing factor SC35
    basic FUNCTION
  • regulating negatively the members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK,SAPK/JNK,p38) which is associated with cellular proliferation and differentiation
  • participating in nuclear mRNA metabolism
  • playing important roles in signal transduction,cell cycle progression and tumor suppression
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    nuclear mRNA metabolism
    a component
  • associated with RNA and/or RNP complexes
  • INTERACTION
    DNA binding to single strand
    RNA binding
    small molecule
    protein
  • binding to RNP complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS