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FLASH GENE
Symbol ERP29 contributors: mct - updated : 24-08-2011
HGNC name endoplasmic reticulum protein 29
HGNC id 13799
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1472 - 261 - 2011 20920593
2 - 1333 - 53 - 2011 20920593
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Nervousbrain   highly Homo sapiens
 brainhindbraincerebellum   Homo sapiens
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
endocrinethyroid
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular Hydrophilic
STRUCTURE
motifs/domains
  • N terminal hydrophobic signal sequence, resembling the thioredoxin domain of protein disulfide isomerase, but lacking its redox-active function due to the absence of an active motif consisting of double cysteines
  • C terminal endoplasmic reticulum retention motif KEEL, but lacking the CXXC thioreduxin box motif
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to rattus Erp29
    intraspecies homolog to AGR2, TXNDC12
    Homologene
    FAMILY protein disulfide isomerase family
    CATEGORY chaperone/stress , enzyme , tumor suppressor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a role in the processing of secretory proteins within the endoplasmic reticulum
  • having a function in thyroid cells connected with folding and/or secretion of thyroglobulin
  • ERP29 function is critical for the folding/secretion of thyroglobulin (Tg), a major secretory product of thyroid cells
  • new role for ERP29 as a chaperone that helps stabilize monomeric GJA1 to enable oligomerization to occur in the Golgi apparatus
  • facilitates the transport of secretory proteins in the early secretory pathway
  • facilitates processing and transport of proteins in the early secretory pathway
  • biological role as a putative chaperone in the endoplasmic reticulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • dimerization of ERP29 is crucial for its protein unfolding function
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates GJA1 trafficking and function
  • physical interaction with EIF2AK3 and moreover, overexpression of ERP29 enhanced endogenous levels of EIF2AK3 (ERP29 regulates response to doxorubicin by a EIF2AK3-mediated mechanism)
  • interplay between MAPK14 phosphorylation and DNAJC3 upregulation has key roles in modulating ERP29-induced cell-growth arrest and survival
  • cell & other
    REGULATION
    Other not responsive to metabolic stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly inhibits proliferation and suppresses tumorigenesis by modulating ER stress signaling and the mesenchymal-epithelial transition in breast cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    in mice Erp29 may be one of the important factors involved in sperm fertilization by facilitating sperm-oocyte membrane fusion