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FLASH GENE
Symbol WNK2 contributors: mct - updated : 15-06-2011
HGNC name WNK lysine deficient protein kinase 2
HGNC id 14542
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 6834 - 2217 - 2001 11571656
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveintestinesmall intestine    Homo sapiensAdult
 intestinelarge intestinecolon   Homo sapiensAdult
Nervousbrain   predominantly Homo sapiens
 brainforebraincerebral cortex highly Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
 braindiencephalonthalamus   Homo sapiens
Olfactory (smell)olfactory bulb     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatum    Homo sapiensAdult
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
NervousPurkinje cell Homo sapiens
Nervouspyramidal cell Homo sapiens
cell lineage
cell lines various cell lines
fluid/secretion
at STAGE
physiological period fetal
Text
  • in neocortical pyramidal cells, thalamic relay cells, and cerebellar granule and Purkinje cells in the developing brain
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a small N-terminal domain followed by a kinase domain
  • a cysteine in place of a lysine in catalytic subdomain II
  • the WNK kinase sequence signature within the subdomains I and II
  • regulatory C-terminal including a highly conserved acidic motif and two coil-coil domains
  • HOMOLOGY
    Homologene
    FAMILY
  • MEKK protein kinase family
  • Ser/Thr protein kinase family
  • WNK (with-no-lysine [K]) subfamily of protein kinases
  • CATEGORY enzyme , antigen , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • cytoplasmic serine-threonine kinase containing cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases
  • involved in the modulation of growth factor-induced cancer cell proliferation through the MAP2K1/ERK1/2 pathway
  • candidate tumor suppressor gene, having potentially a coordinated activity of WNK kinases in the regulation of cell proliferation
  • cell growth regulator that modulates activation of the ERK1/2 protein kinase and is epigenetically silenced in gliomas
  • controls a RhoA-mediated cross-talk mechanism that regulates the efficiency with which MAP2K1 can activate ERK1/2 upon growth factor stimulation
  • with WNK1, WNK3, WNK4, have vital roles in the control of salt homeostasis and blood pressure
  • negatively regulate epidermal growth factor receptor signaling via inhibition of MAP2K1
  • role for WNK2 in the regulation of SLC12A2, SLC12A5 in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling
  • might activate SLC12A2 indirectly via STK39
  • control GTP-loading of RAC1, a signalling guanosine triphosphatase involved in cell migration and motility
  • tumour-suppressing role of WNK2 that is related to RAC1 signalling and tumour cell invasion and proliferation
  • important role for WNK2 in the control of glia-derived cell migration and tumorigenic growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a protein complex in the mammalian brain with STK39, a known phosphoregulator of SLC12A2
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • promotes Cl- accumulation by reciprocally activating SLC12A2 and inhibiting SLC12A5 in a kinase-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    aberrantly methylated in 83p100 and 71p100 of grade II and III meningiomas, respectively
    tumoral     --low  
    by promoter methylation in 17.5 p100 of adult gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS