basic FUNCTION
| activated in WNT signal transduction |
|
may play a role in the signal transduction pathway mediated by multiple WNT genes |
|
DVL2 and beta-catenin are crucially important substrates for tyrosine phosphorylation in the canonical Wnt/beta-catenin pathway |
|
DVL1, DVL2, DVL3 are core components in the correct routing and transmission of canonical and non-canonical Wnt signals, most likely by acting in large multiprotein complexes |
|
involved in the activation of a spindle assembly checkpoint (SAC) kinase, RPS27, and the recruitment of other SAC components, BUB1 and BUBR1, to the kinetochores |
|
involved in mitotic progression by regulating the dynamics of MT plus-ends and the SAC in PLK1-dependent and -independent manners |
|
may be required for spindle orientation but not for bipolar spindle formation |
|
regulator for faithful mitotic progression |
|
DVL2 has potentially an inhibitory role in myogenesis and STAU1 coordinates myogenesis through the regulation of DVL2 mRNA |
|
SESTD1, DVL2 and DACT1 co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development |