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FLASH GENE
Symbol STX12 contributors: mct - updated : 14-09-2015
HGNC name syntaxin 12
HGNC id 11430
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3098 - 276 - 1998 9507000
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
potential coiled-coil domains and a C-terminal hydrophobic tail.
HOMOLOGY
Homologene
FAMILY
  • syntaxin family
  • CATEGORY receptor , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • playing a role in intracellular protein transport
  • STX12, FLOT1, and ABCA1 were identified as phagosomal proteins, indicating the involvement of the phagosomal compartment in ABCA1-mediated lipid efflux
  • regulates cargo delivery from recycling endosomes during melanosome biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with VAMP3 and SNAP23, have a role in the trafficking of MMP during degradation of ECM substrates and subsequent cellular invasion
  • WNK4 inhibits plasma membrane targeting of SLC12A3 through regulation of STX12 SNARE formation
  • STX12 translation is regulated by MTOR in injured neurons to promote axon regeneration
  • mutual dependency between STX13 and VAMP7 in regulating their localization for efficient cargo delivery to melanosomes
  • RAB9A and its co-regulatory GTPases control STX12-mediated cargo delivery to maturing melanosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS