Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC36A1 contributors: mct/npt/pgu - updated : 30-03-2022
HGNC name solute carrier family 36 (proton/amino acid symporter), member 1
HGNC id 18761
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 5821 53 476 - 2009 19549785
11 - 5772 - 386 - 2009 19549785
12 - 5831 - 448 - 2009 19549785
2 - 1017 - 243 - 2009 19549785
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine    Homo sapiensAdult
Nervousbraindiencephalonhypothalamus  
 brainforebraincerebral cortex  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly Homo sapiens
Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiensAdult
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroid Homo sapiens
Digestiveenterocyte Homo sapiensAdult
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cytosolic N terminal domain (three consensus eleven transmembrane domains, N glycosylation sites)
  • a consensus tyrosine-based targeting signal in the cytosolic N-terminal region, which facilitates its expression on the lysosome
  • a disulfide bond between Cys-180 and Cys-329 (disulfide bridge linkage of extracellular loop (EL) 2 and EL 4 is therefore essential for transport function but not for membrane localization)
  • two primary functional domains: one promoting translation repression and P-body assembly and a second domain promoting mRNA decapping after assembly of the mRNA into a P-body mRNP
  • RNA binding protein and multidomain protein that functions at multiple stages in the process of translation repression and mRNA decapping
  • HOMOLOGY
    interspecies homolog to murine Viaat
    intraspecies paralog to SLC36A2
    Homologene
    FAMILY
  • AAAP family (amino acid/auxin permease)
  • solute carrier family 36
  • CATEGORY RNA associated , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    text
  • localized mainly to the apical membrane of intestine epithelial cells and is also found in lysosomes in brain neurons
  • basic FUNCTION
  • amino acid transporter involved in the efflux of lysosomal products (Pro-ALa-gly) from the organelles lumen to cytosol
  • RNA binding protein and a multidomain protein that functions at multiple stages in the process of translation repression and mRNA decapping
  • major route by which small neutral amino acids are absorbed after intestinal protein digestion
  • mediates the uptake of small neutral amino acids at the apical membrane of intestinal epithelial cells after protein digestion
  • H(+)-coupled, pH-dependent, Na(+)- and Cl(-)-independent, low-affinity, high-capacity transporter for taurine and beta-alanine
  • may be responsible for bulk taurine uptake during a meal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction with the basolateral sorting signal of APP/APLPs (functional link between APP/APLPs transport and their processing)
  • binds RNA and has numerous domain-specific interactions with mRNA decapping factors
  • SLC36A1 has a relatively low affinity for its substrates, which include zwitterionic amino and imino acids, heterocyclic amino acids and amino acid-based drugs
  • is an essential mediator of AA-dependent MTOR activation
  • 5-aminolevulinic acid (ALA) appears to be transported into erythroid cells mainly by SLC36A1 and is utilized to generate heme
  • SLC36A1 can likely negatively regulate MTOR by controlling the cellular nutrient signal level
  • SLC38A9 interacted with SLC36A1 and they enhanced each other's expression levels and locations on the lysosomal surface
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS