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FLASH GENE
Symbol CYFIP2 contributors: mct - updated : 18-12-2018
HGNC name cytoplasmic FMR1 interacting protein 2
HGNC id 13760
RNA
TRANSCRIPTS type messenger
text variants 1, 2, and 3 all encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
31 - 6498 145.5 1253 - 2018 29752658
- - 6791 145.5 1253 - 2018 29752658
31 - 6625 145.5 1253 - 2018 29752658
32 - 6574 - 1278 - 2018 29752658
30 - 6421 - 1227 - 2018 29752658
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to CYFIP1
Homologene
FAMILY
  • CYFIP family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text colocalized with FMRP and ribosomes
    basic FUNCTION
  • CYFIP2 could be implicated in the dendritic spine phenotype of fragile X syndrome
  • misregulation of CYFIP2 function and its GRM1-induced expression contribute to the neurobehavioral phenotypes of fragile X syndrome
  • CYFIP2 is part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein complex, which has been implicated in actin polymerization at synapses, a process thought to be required for memory formation
  • is a major significant genetic factor underlying binge eating
  • CYFIP2 regulates the innate startle threshold by reducing neural activity in a small group of excitatory hindbrain interneurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to FXR1, FXR2, FMR1
  • CYFIP2 is a direct TP53 target gene that may be part of a redundant network of genes responsible for TP53-dependent apoptosis
  • NCKAP1 interacts directly with CYFIP2
  • NUAK2 may regulate CYFIP2 expression to promote cervical cancer (CC) cell proliferation, migration, invasion and EMT
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE65
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in autism spectrum disorder (ASD)
    constitutional     --low  
    reduced CYFIP2 expression triggers a cascade of change towards Alzheimer disease, including amyloid production, tau hyperphosphorylation and memory loss
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CYFIP2 and RBBP9 are two novel ALS (amyotrophic lateral sclerosis) potential biomarkers in non-neural tissues from ALS patients that may have direct diagnostic and therapeutic implications to the disease
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    could be a potential hub for targeting treatment of the disease
    ANIMAL & CELL MODELS