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FLASH GENE
Symbol NXF2 contributors: - updated : 20-04-2006
HGNC name nuclear RNA export factor 2
HGNC id 8072
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2884 71.6 626 - Herold
  • differing from variant 2 at the 5' UTR
  • encoded protein is identical for both transcript variants
  • - splicing 2346 71.6 626 - Herold
  • differing from variant 2 at the 5' UTR
  • encoded protein is identical for both transcript variants
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-domain required for interaction with KIF17
  • four leucine-rich repeat,RNP-type RNA6 -binding domain-(RBD)
  • a nuclear transport, factor 2 (NF2) like domain and ubiquitine-associated domain
  • a UBA-like domain
  • a RNA recognition motif (RRM) domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Nxf2
    homolog to zebrafish Dr.6607
    homolog to Drosophila sbr
    homolog to C.elegans nxf-1
    intraspecies homolog to NXF1
    Homologene
    FAMILY family of nuclear RNA export factor genes
    CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    text associated with the nuclear envelope
    basic FUNCTION
  • involved in mRNA export from the nucleus to the cytoplasm
  • a nucleo-cytoplasmic mRNA transporter, playing additional roles in the cytoplasmic localization of mRNAs through interactions with cytoplasmic motor proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • mRNA-nucleus export
  • protein-nucleus import
  • PATHWAY
    metabolism
    signaling
    a component heterodimerized with NXT1 AND NXT2
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • NXT1
  • NXT2
  • E1B-AP5
  • the REF proteins
  • nucleoporins (Nup62, Nup153 and Nup214)
  • interacting with KIF17
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS