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FLASH GENE
Symbol EDEM3 contributors: mct - updated : 07-09-2021
HGNC name ER degradation enhancer, mannosidase alpha-like 3
HGNC id 16787
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 6837 - 932 - 218 29784879
21 - 6885 - 948 - 218 29784879
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Reproductivemale systemprostate   
Respiratorylung    
 respiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Class I alpha-mannosidases (glycosyl hydrolase family 47) in its N-terminal domain
  • four consecutive modules defined as GH47, intermediate (IMD), protease-associated (PA), and intrinsically disordered (IDD) domain (
  • a protease-associated motif in its C-terminal region
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Edem3
    Homologene
    FAMILY glycosyl hydrolase 47 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • alpha1,2-mannosidases activity
  • enhancing endoplasmic reticulum-associated degradation (ERAD)
  • is a regulator of blood triglyceride (TG)
  • EDEM3 provides a unique ERAD timing to misfolded glycoproteins, not only by its mannose trimming activity, but also by the positive and negative feedback modulated by the protease-associated and intrinsically disordered domain, respectively
  • involved in the endoplasmic reticulum-associated degradation pathway, responsible for the recognition of misfolded proteins that will be targeted and translocated to the cytosol and degraded by the proteasome
  • participates in mannose trimming from total glycoproteins
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TXNDC5, an ER-resident oxidoreductase, associates stably with EDEM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2V
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS