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FLASH GENE
Symbol RGS8 contributors: mct - updated : 21-12-2011
HGNC name regulator of G-protein signaling 8
HGNC id 16810
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 polyA site 912 20.8 180 . brain-specific 2002 12110731
  • 9 aa in the N terminus of RGS8 contribute to the function to inhibit Gq-coupled signaling in a receptor type-specific manner
  • 6 - 783 22.8 198 - 2002 12110731
    - splicing - - - - 2002 12110731
  • regulatory function of RGS8S is especially diminished on Gq-coupled responses
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MPRR at the N-terminus, that is the PPP1R9B-binding site
  • HOMOLOGY
    interspecies ortholog to rattus Rgs8
    Homologene
    FAMILY
  • regulator of G protein family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a role in suppression of Gq signaling in a receptor type-specific manner (diminished role for RGS8S)
  • indirect binding of RGS8 to the CHRM1 through PPP1R9B for an efficient regulatory function
  • recruitment of RGS8 to the receptor differentially affects the function of RGS8 among receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms
  • PPP1R9B is a RGS8-interacting protein (CHRM1 and PPP1R9B compete for binding to RGS8)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS