basic FUNCTION
| phosphorylating phosphoinositide |
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regulates both the endosomal and autophagic pathways |
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specifically catalyzes the formation of phosphatidylinositol-3-phosphate (PI3P) |
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essential for neuronal integrity and survival |
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plays important roles in the endocytic and autophagic pathways, both of which are essential for maintaining neuronal integrity |
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phosphatidylinositol 3-kinase class III sub-complex containing PIK3R4, PIK3C3, BECN1, UVRAG and SH3GLB1 regulates cytokinesis and degradative endocytic traffic |
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regulate various intracellular membrane trafficking events |
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plays an essential role in regulating functional autophagy and is indispensable for normal liver and heart function |
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is necessary for autophagic flux in the heart, and PIK3C3 ablation leads to heart failure and death |
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essential role of PIK3C3 in regulating autophagy, and liver and heart function |
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is required for the maintenance of na |
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ve T cells, acting in a cell-intrinsic manner |
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PIK3C3-dependent canonical autophagy plays a critical role in maintaining T-cell homeostasis by promoting T-cell survival through quality control of mitochondria |
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is a major regulator of endolysosomal pathways in podocytes, suggesting the fundamental roles of endocytosis and fluid-phase uptake for the maintenance of the glomerular filtration barrier |
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indispensable role for PIK3C3 in the regulation of intracellular vesicle trafficking and processing to protect the normal cellular metabolism, structure and function of podocytes |
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activity of the PIK3C3/PIK3R4 complex is critical in disease conditions such as autophagic vacuolar myopathy (AVM), and possibly a variety of other lysosomal storage diseases |
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plays a critical role in intracellular membrane trafficking and autophagy induction |