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FLASH GENE
Symbol PIK3R3 contributors: mct - updated : 05-12-2018
HGNC name phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
HGNC id 8981
RNA
TRANSCRIPTS type messenger
text transcripts 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 5194 - 461 highly in testis Suzuki, Dey (1998)
- splicing 5693 - 461 highly in testis Dey (1998)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal YXXM motif, two SH2 domains, binding site
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine P55pik
    Homologene
    FAMILY
  • PI3K p85 subunit family
  • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • interacting with the IGFIR and INSR and may be involved in PI 3-kinase activation by these receptors
  • 1-phosphatidylinositol-3-kinase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IGF1R or INSR
  • ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT1 and up-regulation of MIA3, thereby regulating endothelial cell functions directly relevant to atherosclerosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS