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FLASH GENE
Symbol CHPT1 contributors: mct/npt - updated : 07/11/2008
HGNC name choline phosphotransferase 1
HGNC id 17852
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1530 45 406 testis, colon, small intestine, heart, prostate, spleen Henneberry, Ghosh (2002)
- splicing 1520 - 218 . testis, colon, small intestine, heart, prostate, spleen, not expressed in iris and RPE Henneberry, Ghosh (2002)
lacking the TM segments
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
 salivary gland   highly
Hearing/Equilibriumear   highly
Reproductivemale systemtestis  highly
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CDP-alcohol phosphotranferase motif with the final two Asp residues
  • HOMOLOGY
    intraspecies paralog to CEPT1
    Homologene
    FAMILY
  • CDP-alcohol phosphatidyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • catalyzing the transfer of phosphocholine from diphosphocholine (CDP) to diacylglycerol (DAG) with the release of CMP and formation of phosphatidylcholin (CP)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancerous breast epithelial cell line when compared to that of normal non-tumorigenic breast epithelial cell line
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS