basic FUNCTION
| ADP ribosylation factor (ARF) GTPase activating protein,phosphatidyl 4,5 biphosphate (PIP2)-dependent |
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regulator and coordinator of cell growth, actin cytoskeletal organization and ARF nucleotide cycle |
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cycling with FA proteins when cells are stimulated to move |
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plays a crucial role in the invasive activities, such as matrix degradation activity |
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monoubiquitination, but not poly-ubiquitination, is necessary to be involved in invasive activities |
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like IKBKG, functions as a component of the endocytic recycling compartment |
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plays a role in prostate cancer metastasis |
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mediates GTP hydrolysis on ARF4 and functions as an ARF4 effector that regulates budding of post-TGN carriers, along with IKBKG and RAB11A |
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critical target of tyrosine kinase signaling involved in the regulation of podosomes and invadopodia and potentially may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain and phosphorylation by Src |
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present in cell structures required for cell migration and invasion, such as focal adhesions, invadopodias, and podosomes, and are involved in endocytosis and cytoskeletal remodeling |
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involvement in carcinogenesis and metastasis highlights the importance of the presented structure in general and the Ca2+-binding pocket in particular as it may give clues for designing inhibitors for therapeutic applications |
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plays an important role in the progression and metastasis of ovarian cancer |
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RAB11FIP3 acts synergistically with ASAP1 to direct RAB3IP in ciliary receptor targeting |
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is involved in actin and membrane remodeling and has been associated with podosomes |
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regulates F-actin-based structures and functions, including focal adhesions (FAs) and circular dorsal ruffles (CDRs), cell spreading and migration |
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may directly link signaling and the mechanical machinery of cell migration |