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FLASH GENE

Symbol

CTAG2

contributors: - updated : 02-11-2004

HGNC name	cancer/testis antigen 2
HGNC id	2492

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed LAGE-1A - splicing 7550 - 180 - Lethe LAGE-1B - splicing 1002 21 210 - Lethe exon 1 joined to exon 2 CAMEL - - 680 - 109 - Aarnoudse IL + CAMEL - - 990 - - - - alternative frame starting from the second ATG

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument melanocyte

cell lineage
cell lines	melanoma cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two glycine-rich regions
	a hydrophobic stretch near the C-terminus

HOMOLOGY

intraspecies

homolog to CTAG1B

Homologene

FAMILY

NY-ESO-1 family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

tumor antigen that may serve as a target for immunotherapy

CELLULAR PROCESS	cell life

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

deoxy-azacytidine in lymphoblastoic cells

inhibited by

silenced by DNA methylation

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS