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FLASH GENE
Symbol SLC14A2 contributors: mct/npt - updated : 20/12/2008
HGNC name solute carrier family 14 (urea transporter), member 2
HGNC id 10919
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 4167 - 920 - Smith (2006)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Reproductivefemale systemovary   
 male systemtestis   
Urinarykidneynephron   
 kidneytubule   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine transmembranes domains
  • HOMOLOGY
    Homologene
    FAMILY
  • urea transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text descending thin limbs of Henle foop and descending vasa recta
    basic FUNCTION
  • participating in urinary recycling processes which minimize urea escape from the inner medulla
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS excretion , facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by changes in dietary protein content and hydration state, independently of SLC14A1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to variation in blood pressure
    Variant & Polymorphism SNP Ile 227, Ala357 associated with low pressure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS