Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CLK4 contributors: - updated : 29-08-2006
HGNC name CDC-like kinase 4
HGNC id 13659
RNA
TRANSCRIPTS type messenger
text
  • multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2000 - - heart, muscle, kidney, liver Schultz
    - - splicing 2800 - - heart,muscle,kidney Schultz
    - - splicing 4500 - - kidney, liver, heart Schultz
    - - - 2524 57 481 - Schultz
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     liver   highly
    Nervousbrain    
    Urinarykidney    
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  predominantly
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus Clk4 (97.5pc)
    ortholog to murine Clk4 (97.1pc)
    ortholog to chicken CLK4 (83.6pc)
    Homologene
    FAMILY
  • CDC2/CDC28-like kinase family
  • Ser/Thr protein kinase family
  • Lammer subfamily
  • CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • phosphorylating serine- and arginine-rich proteins of the spliceosomal complex
  • may be a constituent of a network of regulatory mechanisms that enable serine- and arginine-rich proteins to control RNA splicing
  • required for the regulation of alternative splicing of MAPT/TAU
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols)
  • UBL5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS