basic FUNCTION
| plays an important role in the maintenance of genome integrity |
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having functions in the replicational stress response, and involved in the resolution of alternate DNA structures that impede replication |
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helicase interacting directly with the BRCT domain of BRCA1 and contributing to its DNA repair function |
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essential tumor suppressor, required for DNA damage-induced checkpoint control during the transition from G2 to M phase of the cell cycle |
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having a function in the Fanconi anemia pathway that is independent of BRCA1 and downstream of FANCD2 activation |
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BRCA1-associated DNA helicase that contributes to homologous recombination and cross-link repair |
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having a role in the maintenance of potentially unstable genomic G/C tracts during replication |
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may play a role in a homologous recombination pathway of double strand break repair |
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roles of RPA1, BRIP1, and other DNA helicases in the metabolism of damaged DNA that can interfere with basic cellular processes of DNA metabolism |
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can inhibit RAD51 strand exchange, an activity that is likely to be important for its role in controlling DNA repair through homologous recombination |
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likely may perform its catalytic functions in DNA repair and stabilization of the replication fork by displacing DNA-bound proteins or unwinding alternate DNA structures that interfere with normal DNA transactions and lead to genomic instability |
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senses oxidative base damage in either strand of duplex DNA and unwinds the damaged DNA substrate in a strand-specific manner |
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with TOPBP1, are required for ATR-dependent phosphorylation events in response to replication stress |
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when unable to bind BRCA1, promotes poleta-dependent bypass |
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helicase that has been implicated in the maintenance of genomic stability |
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BRIP1 catalytic activity and its effect on BLM protein stability contribute to preservation of genomic stability and a normal response to replication stress |
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stimulates homologous recombination, which depends on the integrity of the helicase domain |
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BRIP1 acetylation facilitates DNA end processing required for repair and checkpoint signaling |