basic FUNCTION
| central regulator of intestinal absorption and iron recycling by macrophages |
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type II acute phase reactant, key mediator of anemia of inflammation |
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defensin-like peptide produced by the hepatocytes in response to iron and inflammation, and is a central humoral mediator of innate immunity and host defense |
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play a key role in the regulation of iron efflux from enterocytes, macrophages, and hepatocytes |
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having iron-regulatory role in the renal tubular system (eliminated by the kidney but is also synthesized in the kidney tubular system), possibly in connection with the iron transporter divalent metal transporter-1 |
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having a primary role hormonal, serving as a negative regulator of iron homeostasis |
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iron-regulatory protein that is upregulated in response to increased iron or inflammatory stimuli |
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reduces serum iron and induces iron sequestration in the reticuloendothelial macrophages |
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peptide hormone that is secreted by the liver and controls body iron homeostasis |
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regulates iron homeostasis by binding to ferroportin, an iron exporter, on the cell surface of target cells and facilitating ferroportin degradation |
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hepatic peptide hormone, negatively regulating iron efflux from the intestines into the blood |
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physiologically important peptide hormone in the regulation of iron levels in the body |
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downregulates ferroportin mRNA, thus uncovering a novel function of hepcidin in iron homeostasis |
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through an active transport mechanism, transported into RPE cells, suggesting that this peptide might have some, hitherto unrecognized, intracellular function |
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showed age and sex dependent variations that correlated with ferritin but not with serum iron and transferrin saturationb |
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HFE2 and HAMP play a critical role in retinal iron homeostasis |
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liver-derived antimicrobial peptide that regulates iron absorption and is also an integral part of the acute phase response |
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is a prototypical antioxidant response or cytoprotective gene within the NFE2L2 transcriptional circuitry |