Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WRAP73 contributors: mct - updated : 04-01-2017
HGNC name WD repeat containing, antisense to TP73
HGNC id 12759
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - splicing 4400 - - heart, brain, liver, prostate, skeletal muscle, pancreas, thymus 2016 26675238
- - splicing 1640 - - brain, liver, thymus, prostate, testis, colon, small intestine 2016 26675238
12 - 1708 51 460 - 2016 26675238
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
 tonsils   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone   
Connectivecartilage   
cells
SystemCellPubmedSpeciesStageRna symbol
 chondrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two WD repeats
  • HOMOLOGY
    intraspecies homolog to HPRP4P
    Homologene
    FAMILY
  • WD repeat gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • inhibitor of endochondral ossification (role in regulation of ectopic ossification)
  • the conserved WRAP73-SSX2IP complex plays a critical role in controlling proper spindle length and orientation
  • satellite and centriolar component
  • WRAP73 and CEP135 have strongly overlapping functions in ciliogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WRAP73 formed a complex and partially colocalised with SSX2IP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WRAP73 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component CEP135
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS