basic FUNCTION
| signal transducer and transcriptional modulator that mediate multiple signaling pathways |
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with PRKX are required for PMA-induced cell attachment and spreading |
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signal-transduction protei |
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involved in the inhibition of TGFB/BMP signaling pathway by competing with MADH4 for receptor activated MADH1 |
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facilitates the degradation of TBX6 through recruitment of SMURF1, reducing TBX6-mediated Myf5 gene activation |
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associated with a reduced survival in lung cancer patients, playing a critical role in supporting lung cancer cell growth and survival and its targeted inactivation may provide a novel therapeutic strategy for lung cancer expressing SMAD6 |
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negatively regulating IL-1R-Toll-like receptor signals and promoting TGB-beta-mediated anti-inflammatory effects |
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enhancing SMURF1-induced RUNX2 degradation in an ubiquitin-proteasome-dependent manner |
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regulating glucocorticoid actions as a corepressor of the glucocorticoid receptor and may contribute to the neuroprotective, anticatabolic and pro wound healing properties of the TGFbeta family of proteins |
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required for promoting neuronal progenitor cells to exit the cell cycle and differentiate into neurons |
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promotes neuronal differentiation by inhibiting both the BMP and the Wnt/beta catenin pathways in the developing dorsal spinal cord |
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indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells (HSCs) |
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UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis |
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is a regulatory molecule which regulates the proliferation, self-renewal and WNT/CTNNB1 signaling in hepatic progenitor cells (HPCs) |