shorter carboxyl terminal amino acid sequences than 12A
12
splicing
3814
-
766
-
Kobayashi, Ohashi-Kobayashi (2006)
EXPRESSION
Type
widely
expressed in
(based on citations)
organ(s)
System
Organ level 1
Organ level 2
Organ level 3
Organ level 4
Level
Pubmed
Species
Stage
Rna symbol
Digestive
intestine
small intestine
highly
Lymphoid/Immune
thymus
highly
Nervous
brain
moderately
spinal cord
Reproductive
female system
uterus
cervix
highly
male system
testis
highly
Visual
eye
highly
tissue
System
Tissue
Tissue level 1
Tissue level 2
Level
Pubmed
Species
Stage
Rna symbol
Nervous
central
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N-terminal four transmembrane helices would be separately located from the core domain helices and may well interact with cellular components required for its lysosomal targeting (Kamakura 2008)
one ATP binding
one transmembrane (1TM) domain with ten potential transmembrane helices followed by a conserved ABC region
detected in the lysosomal compartment co-localizing with the lysosome-associated membrane protein LAMP2, and LAMP1
basic FUNCTION
half-ABC transporter, traffic ATPase, may play a role in lysosomes
involved in multidrug resistance as well as antigen presentation
may be the key link missing in the chaperone-mediated autophagy and a novel route discharging cytosolic antigens in lysosomal compartments induced in professional antigen-presenting cells
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
induced by
during differentiation of monocytes to dendritic cells and to macrophages