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FLASH GENE
Symbol DNAH2 contributors: mct - updated : 06-09-2022
HGNC name dynein, axonemal, heavy polypeptide 2
HGNC id 2948
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
86 - 14563 - 4427 - 1997 9256245
14 - 3011 - 872 - 1997 9256245
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Respiratoryrespiratory tracttrachea   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY motor/contractile , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
basic FUNCTION
  • inner dynein arm heavy chain, having ATPase activity
  • involved in intracellular movement of organelles and vesicles or in the orientation of the mitotic spindle apparatus
  • DNAH2 may modulate the cell homologous recombination repair partially by increasing the ubiquitination and the enrichment to DNA damage sites of FANCD2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other interacting with microtubules
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF45
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS