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FLASH GENE
Symbol GRB7 contributors: mct - updated : 24-09-2013
HGNC name growth factor receptor-bound protein 7
HGNC id 4567
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2260 - 532 - 1996 8940081
15 - 2116 - 532 - 1996 8940081
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
Endocrinepancreas    
Reproductivefemale systemuteruscervix highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal proline-rich region,
  • a Ras-GTPase binding domain,
  • a PH domain, mediating GRB7 binding to phospholipids
  • an SH2 domain and a BPS domain in between the PH and SH2 domains , and SH2 can directly bind to the autophosphorylated PDGF beta-receptor
  • HOMOLOGY
    interspecies homolog to C.elegans newly identified gene
    Homologene
    FAMILY
  • GRB7/10/14 family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating the coupling of multiple cell surface receptors to downstream signaling pathways in the regulation of various cellular functions
  • has potential importance in the progression of cancer
  • implicated as a downstream mediator of integrin-PTK2 signal pathways in the regulation of cell migration
  • implicated in PDGF signaling pathways in certain cell types by binding to the receptor directly or indirectly via SHC1
  • plays an important role in hepatocellular carcinoma progression and is strongly associated with expression of FAK
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction with both LY6G6F and GRB2 is mediated through its Src homology 2 domains and is dependent on the phosphorylation of LY6G6F
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    plays pivotal roles in activating signal transduction and promoting tumor growth in breast cancer cells with chromosome 17q11-21 amplification
    tumoral     --over  
    in invasive esophageal carcinomas
    tumoral   amplification    
    with ERBB2 in primary gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    GRB7 peptide inhibitor appears to be a promising molecularly targeted therapeutic agent against metastatic pancreatic cancer
    cancer  
    has potential to be developed as a therapeutic agent alone, in combination with traditional chemotherapy, or in combination with other targeting molecules, in several cancer
    ANIMAL & CELL MODELS