basic FUNCTION
| playing an important role in the homeostasis of the dermal extracellular matrix and the dynamic equilibrium between matrix synthesis and proteolytic degradation |
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P cysteine proteinase, exhibiting strong degradative activity against the extracellular matrix and involved in osteoclast-mediated bone destruction |
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likely major lysosomal protein in bone matrix resorption |
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critical protease in synovial fibroblast-mediated collagen degradation |
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having dual functions as a cysteine protease and a regulator of osteoclasts survival, playing a role as a potential regulator of osteoclasts apoptosis and senescence |
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may mediate osteoclasts apoptosis and senescence through the Tp53-dependent pathway |
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lysosomal cysteine protease with strong collagenolytic activity that mediates bone resorption in osteoclasts |
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may play a role in maintaining homeostasis of the extracellular matrix outside of bone |
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may play an important role in melanoma invasion and metastasis by mediating intracellular degradation of matrix proteins after phagocytosis |
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responsible for the degradation of type I collagen in osteoclast-mediated bone resorption |
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playing a role in bone resorption demonstrating its ability to regulate the initiation and termination of the resorption process in an autocrine manner |
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with CTSL, and CTSK, implicated in atherogenesis |
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collagenase activity of cathepsin K requires a highly specific interaction with chondroitin 4-Sulfate (C4-s) |
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late differentiation marker during osteoclastogenesis |
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plays an essential role in abdominal aortic aneurysm (AAA) formation by promoting T-cell proliferation, vascular SMC apoptosis, and elastin degradation and by affecting vascular cell protease expression and activities |
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cysteine peptidase cathepsin K that is a major player in extracellular proteolysis |
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CTSB, CTSK, CTSL1, CTSS may be putative leptin activity regulators in white adipose tissue (WAT) |
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cathepsin K ablation mitigates pressure overload-induced hypertrophy, possibly via inhibition of the mammalian target of rapamycin and ERK pathways |
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major lysosomal collagenase produced by osteoclasts, playing an important role in bone resorption |
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major collagenolytic protease in bone that facilitates physiological as well as pathological bone degradation |
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is organized into elongated C-shaped protease dimers that reveal a putative collagen-binding interface aided by glycosaminoglycans |