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FLASH GENE

Symbol

LAMP1

contributors: mct/npt/pgu - updated : 07-06-2015

HGNC name	lysosomal-associated membrane protein 1
HGNC id	6499

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed LAMP1 9 - 2560 - 417 - 2007 17245426

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly   stomach       highly Endocrine pancreas       highly Nervous nerve       highly Reproductive female system ovary     highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

puberty, pregnancy

Text	placenta
	appears late in spermatogenesis (Acrosome-phase)

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	two extracellular N glycosylation sites
	a transmembrane (1TM) segment
	a short cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Lamp1

Homologene

FAMILY

LAMP family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	presenting carbohydrate ligands to selectins
	could be involved in keratinocyte differentiation, but apparently not through interaction with galectin-3
	LAMP1 and LAMP2 are delivered to phagosomes during the maturation process
	can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts
	LAMP1 and LAMP2 have distinct functions, and the presence of both proteins together is required for the essential regulation of autophagy to avoid embryonic lethality

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

major constituents of lysosomal membranes

INTERACTION

DNA

RNA

small molecule

protein	interacting with AMELX (AMELX interacts with the transmembrane proteins CD63 and LAMP (lysosome-associated membrane protein) 1, which are involved in endocytosis)
	specific receptor for ERAP2, it is not a receptor for M180 amelogenin
	MCOLN1 loss specifically causes, an increase in the lysosomal protease CTSB and the lysosomal membrane protein LAMP1

cell & other

i5 lysosomal associated

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Gaucher disease with severe clinical manisfestations constitutional     --other   differentially expressed in acute and chronic human thymic involution

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	LAMP1 expression may be a sensitive marker for the cytotoxic activity determination
Therapy target

ANIMAL & CELL MODELS