basic FUNCTION
| playing a role in regulation of pre-mRNA splicing and in the stimulation of translation initiation |
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promoting the binding of U2 snRNP to pre-mRNAs |
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acting via the protein degradation ubiquitin-proteasome pathway |
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repressing alpha-actinin SM exon splicing |
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post-transcriptional switch from PTBP1 to PTBP2 controls a widespread alternative splicing program during neuronal development |
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controls the transition from exon definition to an intron defined spliceosome |
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inducing human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site |
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not oncogenic, can either promote or antagonize a malignant trait dependent upon the specific intra-cellular environment |
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inhibits cytomegalovirus replication by interfering with major immediate-early (MIE) gene splicing through competition with U2AF for binding ot the polypyrimidine tract in MIE gene introns |
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PTBP1 and HNRNPL are positive regulators of SLC7A1 mRNA translation via the internal ribosome entry site (IRES) under stress conditions that cause a global decrease of protein synthesis |
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PTBP1 and an HNRNPL, promote the efficient translation of SLC7A1 mRNA during amino acid starvation |
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influences negative strand RNA synthesis of dengue virus |
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promoting pre-mRNA 3' end processing in collaboration with hnRNPH |
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with HNRNPA2B1, and HNRNPA1, have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer |
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abundant RNA-binding protein binding to polypyrimidine tracts, such as those present at or upstream of 3prime splice sites, and that can regulate alternative splicing by creating a zone of silencing |
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PTBP1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by PTBP2 |
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PTBP1 and its brainspecific homologue, PTBP2, are associated with pre-mRNAs and influence pre-mRNA processing, as well as mRNA metabolism and transport |
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widely expressed RNA binding protein that acts as a regulator of alternative splicing and of cytoplasmic mRNA functions |
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functions as a key regulator of alternative pre-mRNA splicing in the nucleoplasm and promotes internal ribosome entry site-mediated translation initiation of viral and cellular mRNAs in the cytoplasm |
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PTBP1 and PTBP2, are also nonconserved cryptic exon repressors, and PTBP1 and PTBP2 are members of a family of cryptic exon repressors |
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PTBP1 and PTBP2 reprogram developmental pre-mRNA splicing in neurons |
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PTBP1 and PTBP2 serve both specific and redundant functions in neuronal pre-mRNA splicing |
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regulates alternative splicing of many target genes involving in tumorgenesis in colon cancer cells |
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PTBP1 was required for proper expression of the MYC-dependent gene program induced in germinal centers (GCs) B cells receiving T cell help and directly regulated the alternative splicing |
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contributes likely to spermatogenesis through regulation of spermatogonia proliferation |
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is essential for the humoral immune response |
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PTBP1 induces bladder cancer Lymph node metastasis and proliferation through an alternative splicing mechanism |
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translational regulation of PTBP1 protein levels during the cell cycle, which may affect downstream regulation of alternative splicing and translation mediated by PTBP1 protein isoforms |
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PTBP1 controls mRNA abundance and alternative splicing of important cell cycle regulators including CCND2, MYC, RBL1 and CDC25B |
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PTBP1, PTBP2 are essential for B cell development |