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FLASH GENE
Symbol PSMA6 contributors: mct - updated : 07-06-2016
HGNC name proteasome (prosome, macropain) subunit, alpha type, 6
HGNC id 9535
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1016 - 227 - 2013 22882272
7 - 1139 - 167 - 2013 22882272
7 - 1091 - 246 - 2013 22882272
6 - 996 - 167 - 2013 22882272
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung   moderately
Skin/Tegumentskin   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Psma6
Homologene
FAMILY to peptidase family T1A.
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between PPP3CA and the 20S proteasome subunit PSMA6 that increased intracellular proteasomal activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Graves disease
  • to myocardial infarction
  • myocardial infarction and coronary artery disease
  • Variant & Polymorphism SNP , other
  • 189- and 191-bp alleles of HSMS006 were much less frequent in Graves' disease patients
  • increasing the risk of myocardial infarction
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS