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FLASH GENE
Symbol GTF3A contributors: mct/npt - updated : 04-11-2009
HGNC name general transcription factor IIIA
HGNC id 4662
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1404 - 365 - Hanas (2002)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
not specificadipocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine C2H2 zinc finger domains
  • a non-finger C-terminal tail with conserved transcription activation domain as well as conserved nuclear localization and nuclear export signals (Hanas 2002)
  • HOMOLOGY
    interspecies homolog to Xenopus
    homolog to C.elegans T08b2.11
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • required for initiation of transcription of 5s RNA
  • initiating transcription of the 5 s ribosomal RNA gene
  • maintaining the stability of transcription of other genes
  • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the internal control region (icr) of approximately 50 bases within the 5S RNA gene
    RNA binding to transcribed 5S RNAs
    small molecule metal binding,
  • Zn2+
  • protein
  • FT3A interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS