SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microfilament
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| intracellular,nucleus
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| remains associated to the centrosome in a proliferative stateand is tightly associated with the centrosome throughout the cell cycle in a microtubule- and dynein-independent manner (Robert 2007) |
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is present in the Golgi of spermatids |
basic FUNCTION
| required for assembly of renal cilium (in mouse) |
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structural constituent of the ribosome, required for Hedgehog (Hh) response |
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required for establishing epithelial polar cell polarity and for convergent extension of the cochlear duct |
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having functions in a ciliogenic pathway or in cilia maintenance (Taulman 2001) |
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playing an essential role for ciliogenesis, and also crucial for G1-S transition in non-ciliated cells (Robert 2007) |
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the microtubule-associated golgin TRIP11 and IFT88 participate in acrosome, head-tail coupling apparatus (HTCA), and tail biogenesis, and defective intramanchette transport of cargos disrupts spermatid tail development |
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is required for spindle orientation in mitosis |
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visual pigments transport to the retinal outer segment despite removal of KIF3A and IFT88, and KIF3A-mediated anterograde IFT88 is responsible for photoreceptor transition zone and axoneme formation |
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intraflagellar transport protein, critical for the cilium, and required for the maintenance of chondrocytes and cartilage |
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is a central component of the intraflagellar transport (Ift) complex B, essential for the building of cilia and flagella from single cell organisms to mammals |
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extraciliary function for IFT88 |
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ciliary protein IFT88 regulates fundamental actin organisation and the stiffness of the actin cortex leading to alterations in cell deformation, mechanical properties and blebbing in an IFT88 chondrocyte cell line |