basic FUNCTION
| adenosine receptor A1, with no likely role of promoters polymorphism in bipolar affective disorders inhibiting adenylate cyclase |
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mediate mobilization of calcium in human bronchial smooth muscle cells |
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its activation is needed for normal rebound synchronized slow-wave activity in sleep, suggesting a functional role for synchronized slow-wave homeostasis |
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critical role for adenosine in bone homeostasis via interaction with ADORA1 |
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regulates SLC1A2 expression in astrocytes |
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ADORA1 and its downstream signaling regulate SLC1A2 mRNA expression and function |
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might regulate ethanol-sensitive SLC1A2 |
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ADORA1 as well as SLC1A2 might regulate ethanol intake |
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ADORA1 and ADORA2B are both involved in differentiation to Treg, but through different mechanisms |
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expression of ADORA1 induced adipocyte differentiation |
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ADORA1, via phospholipase C (PLC)s activation, triggers a nonselective cationic influx occurring through TRPC3 channel |
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Adenosine has a key endogenous neuroprotective role in the brain, predominantly mediated by ADORA1 |
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stimulation of ADORA1 enhances the barrier function in vasa vasorum endothelial cells (VVEC) by activation of the Gi/PI3K/Akt pathway and remodeling of actin microfilament |
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may play a role in the development of atherosclerosis, possibly due to its pro-inflammatory and mitogenic properties |