basic FUNCTION
| ubiquitin-like protein playing a role in immune response |
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may be associated with specialized functions in innate immune system |
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interferon-induced ubiquitin-like modifier, implicated in a variety of biological activities, which encompass antiviral defense, immune responses, and pregnancy |
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having not essential role for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus |
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interacting with, and conjugated to its targets by UBE1L and UBE2E2 |
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enhancing the innate antiviral response by inhibition of IRF3 degradation |
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involved in the conjugation of FLNB, leading to the release of RAC1, MEKK1 and MKK4 from the scaffold protein and thus blocking the JNK cascade activation |
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modifies proteins in a similar manner to ubiquitylation, and protein conjugation by ISG15 is termed ISGylation |
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removes ISG15 from conjugated proteins |
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plays an important role in innate immune responses |
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plays an important role in the regulation of macrophage responses |
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essential role of ISG15 in the cellular immune antiviral response leading to a better understanding of the antiviral responses triggered by ISG15 that may lead to the development of therapies against important human pathogens |
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ISG15 pathway implicated in the regulation of viral entry/uncoating |
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is a previously unrecognized support factor for Cancer stem cells (CSC) in the pancreatic ductal adenocarcinoma (PDAC) microenvironment with a key role in pathogenesis and progression |
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is an interferon-stimulated, linear di-ubiquitin-like protein, with anti-viral activity |
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ISG15-dependent restriction of Listeria infection, reinforcing the view that ISG15 is a key component of the innate immune response |
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unlike ISG15, ubiquitin and UBD are conjugated to a similar degree to newly translated and pre-existing proteins |