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FLASH GENE
Symbol MLLT11 contributors: mct - updated : 03-10-2012
HGNC name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
HGNC id 16997
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2180 - 90 - 2008 17929166
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunethymus   highly
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage highly in neural stem/progenitor cells
cell lines hematopoietic cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
basic FUNCTION
  • cooperates with the NOTCH signaling pathway to foster the emergence of BM prothymocytes and drive subsequent intrathymic specification toward the T-cell lineage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLLT11 up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with HRX (MLL) in infantile acute myelomonocytic leukemia, with translocation t(1;11)(q21;q23)
    tumoral     --over  
    in high-risk myelodysplastic syndrome
    tumoral     --over  
    is a poor prognostic marker for adult patients with normal cytogenetics -acute myeloid leukemia
    tumoral     --over  
    leads to a more progression in breast cancer, at least in part, through regulating the integrin alpha3, ETS1, MMP2, TRIM25 and YWHAD expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS