basic FUNCTION
| transcription regulator, activating matrix metalloproteinase genes |
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involved in in progenitor cell renewal or terminal differentiation |
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acting in synergy with c-Jun and specificity protein 1 to transactivate the proximal region of the MUC4 promoter and increase MUC4 mRNA levels in well differentiated cells |
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play critical roles in tumor metastasis via directly binding to the promoter of genes involved in tumor migration and invasion |
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pivotal and complementary roles of ETV4 and ETV5 transcription factors in events crucial to mammary tumorigenesis |
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sumoylation plays a positive role in ETV4-mediated transcriptional activation and the ERK MAP kinase pathway cooperates with rather than antagonizes this process |
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with ETV5, are key components of a gene network downstream of Ret that promotes and controls renal branching morphogenesis |
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is involved in tumorigenesis especially during the metastatic process |
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increased the morphogenetic and tumorigenic capacity of mammary epithelial cells by modulating their cell morphology, proliferation, and migration potential |
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ETV4 and ETV5 are essential molecules of the transcriptional program linking neurotrophin signaling to sensory neuronal differentiation, suggesting that they can be involved in NGF-mediated target innervation |
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might potentially play an essential role in the activation of the PTK2 gene during tumor metastasis |
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oncogenic factor ETV4 regulates POU5F1 gene expression as a transcriptional activator |
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ETV4 and ETV5, potentially through regulation of GBX2 and TCF15, are involved in the ES cell proliferation and induction of differentiation-associated genes in ES cells |