basic FUNCTION
| required for activity at the locus control region (LCR) upstream of the globin gene complexes |
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USF1 and NFE2 together regulate the association of Pol II with the adult beta-globin gene promoter |
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NFE2 represses protein acetylation and expression of GCM1 in trophoblast cells, preventing excess syncytiotrophoblast formation and permitting normal placental vascularization and embryonic growth |
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may play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the procurement of iron |
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role of increased NFE2 activity in the pathophysiology of myeloproliferative neoplasms (MPNs) |
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by activating genes in megakaryocytes that mediate platelet production and function, NFE2 determines the quantity and quality of platelets |