SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,cytoplasm,cytosolic,vesicle
|
text
| present on the plasma membrane but also localizes to stable intracellular compartments of unknown function, and also found on lysosomes |
basic FUNCTION
| mediating relevant selective cholesterol transport |
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involved in controlling HDL cholesterol, HDL structure and delivery of cholesterol to steroidogenic tissues, and playing a critical role in lipoprotein metabolism, mainly due to its ability to mediate selective high density lipoprotein (HDL) cholesterol uptake concentration |
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playing a role in photoreceptor outer segment lipid binding and uptake by RPE cells in the eye |
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controls high-density lipoprotein (HDL) metabolism by mediating cellular selective uptake of lipids from HDL without the concomitant degradation of the lipoprotein particle |
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role in mediating the selective uptake of cholesterol from HDL in hepatocytes, steroidogenic cells, and other tissues |
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may function in cholesterol trafficking from late endosomes/lysosomes |
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is potentially a critical protective modulator of sepsis |
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plays a significant role in macrophage cholesterol flux that may partly account for its effects on atherogenesis |
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C323 of SCARB1 is critical for SCARB1-mediated HDL binding and cholesteryl ester uptake, and changes in redox status may be a regulatory factor modulating SCARB1-mediated cholesterol transport |
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through interaction with plasma membrane (PM) cholesterol, SCARB1 serves as a PM cholesterol sensor, and the resulting intracellular signaling governs processes in both enterocytes and endothelial cells |
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presence of SCARB1 in extraembryonic tissues is involved in the maternal-fetal transport of cholesterol and/or other lipids with a role during neural tube closure and fetal growth |
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binds HDL and mediates selective delivery of cholesteryl esters (CEs) to the liver, adrenals, and gonads for product formation (bile acids and steroids) |