motifs/domains
| two cytosolic nucleotide-binding domains (NBD1 and NBD2), dimerizing to form composite nucleotide binding sites (NBSs) each containing Walker A and B motifs from one domain and the ABC "C" signature from the other |
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17 putative transmembrane (TM) helices forming three membrane-spanning domains (de Foresta 2010), are linked by extracellular and cytoplasmic loops (multiple roles for cytoplasmic loops 5 in the membrane expression and function of ABCC1) |
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two ATP binding (nucleotide binding fold) |
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one in the N terminus not found in most other ABC transporter |
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two membrane spanning domains (MSDs) each |
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a nucleotide binding domain |
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a third MSD with five transmembrane (TM) helices, whereas MSD2 and MSD3 each contain six TM helices |
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proline residues in the core cytoplasmic |
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transmembrane regions important for transport function, substrate specificity, and nucleotide interactions |
basic FUNCTION
| ATP-binding cassette transporter that confers resistance to drugs(colchicine doxorubicine) and mediates the transport of organic anions |
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glutathione (GSH) cce protein ()onjugate (GS-x) pump or multispecific anion transporter |
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having specific biologic functions in epidermal lipid reorganization during terminal keratinocyte differentiation |
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playing a role in export of sphingosine-1-phosphate from mast cells |
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may play an important role in smoking-related lung function loss and development of chronic obstructive pulmonary disease (COPD) |
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with P-glycoprotein (ABCB1) and the breast cancer resistance protein (ABCG2), confers resistance to a large number of structurally diverse drugs |
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ability to mediate ATP-dependent CBL transport and having a physiologic role in CBL homeostasis |
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mediates the ATP-dependent efflux of a variety of organic anions derived from both endogenous metabolites and exogenous xenobiotics, many of which are conjugated to glutathione |
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its activity is not correlated with the level of free cholesterol or with localization in cholesterol-dependent lipid rafts |