protein
| HAUS6 interacts with the NEDD1-gamma-tubulin complex and recruits this complex to the spindle, which, in turn, promotes microtubule polymerization |
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HAUS6 is a spindle-associated protein, promoting microtubule-dependent microtubule amplification through its interaction with and recruitment of NEDD1, the targeting subunit of the gamma-tubulin ring complex |
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binds directly to TUBG1 through a small region of just 62 AAs at the C-terminus of the protein |
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via the formation of the NEDD1-PLK1 complex and subsequent HAUS8 phosphorylation, PLK11 regulates spindle MT-based MT nucleation to accomplish normal bipolar spindle formation and mitotic progression |
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interaction with NEDD1 is necessary for the centrosome localization of CEP57 |
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CEP192, a centrosomal protein similarly required for spindle formation, associates with NEDD1 and modulates its mitotic phosphorylation (also CEP192 may regulate spindle assembly by modulating NEDD1 function) |
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one important function of AURKA in mitotic cells is to promote MT nucleation around the chromatin by phosphorylating NEDD1, and thereby to promote functional spindle assembly |
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centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures that recruit other centrosomal proteins such as PCM1 and NEDD1 |
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HSPA4 may associate with NEDD1 and TUBG1, two pericentriolar material (PCM) components essential for centrosome maturation and MT nucleation |
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MZT1 specifically binds fully assembled GTuRC to enable interaction with NEDD1 for targeting, and with the CM1 domain of CDK5RAP2 for stimulating nucleation activity |