basic FUNCTION
| increasing the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA |
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indirectly modulates transcription by serving as a regulator for transcriptional elongation as well as for TP53, EAF2, and steroid receptor activities (Zhou 2009) |
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could modulate THBS1 promoter activity in a direct manner and could indeed serve as a transcriptional factor to regulate its expression (Zhou 2009) |
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influences vasculogenesis, at least in part, through up-regulating THBS1 (Zhou 2009) |
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has an early and essential role during rapid high-amplitude gene expression that is required for both Pol II pause site entry and release |
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in addition to its association within super elongation complex (SEC), is also a component of the little elongation complex (LEC) involved in small nuclear RNA (snRNA) gene expression in ES cells |
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is recruited to UV-damaged chromatin in a CDK7- dependent manner |
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is essential for transcription resumption after removal of transcription blocking DNA lesions by the transcription-coupled repair (TCR) machinery |
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ELL and CDK7 play essential yet distinct roles during transcription-coupled repair (TCR) |
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role of ELL in response to DNA damage, providing an insight into the mechanism for KMT2A-ELL-associated leukemogenesis |