basic FUNCTION
| probable mediator of EBV effects on B lymphocytes or of normal lymphocyte functions |
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activating B and T lymphocytes |
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controls migration of memory T cells to inflamed tissues and stimulate dendritic cell maturation |
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promotes metastasis by preventing anoikis in cancer cells |
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is the essential adhesion signal required for the targeting of leukaemic T-cells into the CNS |
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CCR7 and CCL21 contribute to the migratory capacity of the dendritic cells |
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directly activates GATA2 transcription, which is an important gene for the maintenance of hematopoietic stem cells |
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CCR7 mediates entry into the lymph nodes and S1PR1 signaling controls their subsequent exit |
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CCR7-independent transport of skin self-Ags occurs in the dermis |
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eosinophils express CCR7 and have multipotent responses to the known ligands of CCR7 |
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playing no appreciable role in trafficking of central memory CD4 T cells to lymph nodes |