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FLASH GENE
Symbol CCR7 contributors: mct - updated : 05-02-2015
HGNC name chemokine (C-C motif) receptor 7
HGNC id 1608
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2207 40.2 378 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil Homo sapiens
Blood/Hematopoieticneutrophil Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus binds to the N-loop and third beta-strand of CCL21 chemokine domain
  • seven transmembrane segments (7TM) receptor
  • lysine 564 adjacent to the C-terminal binding protein-binding motif is crucial for transcriptional activation of GATA2
  • HOMOLOGY
    interspecies homolog to rattus Ccr7 (86.2pc)
    homolog to murine ccr7 (87.0pc)
    Homologene
    FAMILY
  • G protein coupled receptor/chemokine receptor family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    basic FUNCTION
  • probable mediator of EBV effects on B lymphocytes or of normal lymphocyte functions
  • activating B and T lymphocytes
  • controls migration of memory T cells to inflamed tissues and stimulate dendritic cell maturation
  • promotes metastasis by preventing anoikis in cancer cells
  • is the essential adhesion signal required for the targeting of leukaemic T-cells into the CNS
  • CCR7 and CCL21 contribute to the migratory capacity of the dendritic cells
  • directly activates GATA2 transcription, which is an important gene for the maintenance of hematopoietic stem cells
  • CCR7 mediates entry into the lymph nodes and S1PR1 signaling controls their subsequent exit
  • CCR7-independent transport of skin self-Ags occurs in the dermis
  • eosinophils express CCR7 and have multipotent responses to the known ligands of CCR7
  • playing no appreciable role in trafficking of central memory CD4 T cells to lymph nodes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text inflammatory response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for the MIP-3-beta chemokine (CCL19)
  • high affinity for CCL21
  • chemokine receptor involved in the migration of neutrophils to the lymph nodes
  • CCR7 was found to interact directly with TOPI
  • CCL21 chemokine recruits normal immune cells and metastasizing tumor cells to lymph nodes through activation of the G protein-coupled receptor CCR7
  • after binding to CCL19, CCR7 signaling leads to increased expression and phosphorylation of MAPK7 and up-regulation of KLF2, which results in S1PR1 expression and a migration of T lymphocytes
  • contribution of CCR7 to STAP2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells
  • RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs
  • cell & other
    REGULATION
    induced by Epstein-Barr virus
    Other expression is controlled by the activity of Notch1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells, malignant breast tumors and metastases
    tumoral     --over  
    in muscle fibers in juvenile dermatomyositis
    constitutional     --over  
    of CCL5 and median chemokine receptor 7 (CCR7) mRNA expression in localized scleroderma lesions as compared to healthy controls
    tumoral     --over  
    significantly increased in gastric adenocarcinomas compared to peritumoral tissue
    constitutional     --over  
    exacerbates atherosclerosis by increasing T cell accumulation in atherosclerotic lesions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target CCL21/CCR7 signaling of fibrocytes may provide therapeutic targets for combating renal fibrosis
    ANIMAL & CELL MODELS
  • CCR7-/- mice exhibit profound anomalies in lymph node and spleen architecture, which complicates the study of CCR7-mediated T cell trafficking