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FLASH GENE
Symbol FCGR2C contributors: mct - updated : 13-02-2013
HGNC name Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
HGNC id 15626
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1510 35 323 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticplatelet
Endocrineislet cell (alpha,beta...)
Lymphoid/ImmuneB cell Homo sapiensAdult
Lymphoid/Immunemacrophage
Lymphoid/Immunenatural killer Homo sapiensAdult
cell lineage primarily, by cells of the myeloid lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two Ig extracellular domains
  • a cytoplasmic tail with the immunoreceptor tyrosine based inhibitory motifs (ITIM)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B cells
  • glycoprotein that bind the Fc region of IgG
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to idiopathic thrombocytopenic purpura (ITP)
    Variant & Polymorphism other
  • activating FCGR2C-ORF genotype predisposes to ITP by altering the balance of activating and inhibitory FCGR on immune cells
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS