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FLASH GENE
Symbol SLC7A5 contributors: mct/npt - updated : 25-06-2019
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
HGNC id 11063
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4543 - 507 - Pffeifer (1999)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestiveintestinelarge intestinecolon highly
 liver    
Nervousbrain    
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
Urinarykidney   highly
Visualeyeretina  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver, bone marrow, placenta, testis, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane segments (12TM)
  • cytoplasmic N and C termini with two conserved cysteine residues between TM3 and TM4,
  • the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Slc7a5
    Homologene
    FAMILY
  • amino acid-polyamine-organocation (APC) superfamily
  • L-type amino acid transporter (LAT) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text expressed in various tissues, including the intestinal wall, blood-brain barrier, and kidney (Del Amo 2008)
    basic FUNCTION
  • sodium-independent, high- affinity, transport of large neutral amino-acids, involved in cellular amino-acid uptake
  • AA permease-related protein which for surface expression and function requires formation of disulfide-linked heterodimers with the glycosylated heavy chain of the h4F2/CD98 surface antigen (Pfeiffer 1999)
  • playing a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina
  • with SLC7A8, functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids (Omidi 2008)
  • major transporter of tyrosine in human fibroblast cells (Vumma 21008)
  • may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism (Capelo 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein 4F2 heavy chain (CD98) to form a complex mediating L-type (sodium independent exchange) of large neutral amino acids transport
  • system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCAPD3 down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    has an important role to play in the metastatic process of variable neoplasms and its expression was significantly correlated with cell proliferation and angiogenesis (Kaira 2008)
    tumoral     --over  
    of SLC7A5 is a pathological factor to predict the prognosis in patients with resectable stage I pulmonary adenocarcinoma (Kaira 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • SLC7A5 expression is a promising pathological factor for predicting the prognosis in patients with resectable stage I non-small cell lung cancer (Imai 2009)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS