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FLASH GENE
Symbol GPX2 contributors: mct - updated : 19-10-2022
HGNC name glutathione peroxidase 2 (gastrointestinal)
HGNC id 4554
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 922 - 190 - 2022 35193955
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly Homo sapiens
 intestine     Homo sapiens
 liver    
 stomach   highly Homo sapiens
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • glutathione peroxidase involved in free radical detoxification
  • involved in transcriptional response to exogenous redox agents and catabolic pathway of activated oxygen species
  • H2O2 neutralization by GPX2 is essential for maintaining clonogenic and metastatic capacity, but also for the generation of differentiated proliferating tumor mass
  • GPX2 plays an important role in bladder carcinogenesis through the regulation of apoptosis against intracellular ROS
  • GPX2 and GPX1 have overlapping functions in controlling inflammatory lipid mediator synthesis and, most probably, exert their anti-inflammatory effects by preventing excessive PGE2 production
  • GPX2 regulates the balance between regeneration and apoptotic cell shedding in the intestine
  • unique role for redox signaling by GPX2 dysregulation in breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target of TP63, inhibiting oxidative stress-induced apoptosis in a TP53-dependent manner
  • GPX2, TXNRD2 and TXNRD3 are regulated by WNT signalling in the intestinal epithelium
  • cell & other
    REGULATION
    activated by TP63
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Pancreatic cancer tissues
    tumoral     --over  
    contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be considered as a novel biomarker in bladder cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    GPX2 silencing could inhibit the Wnt pathway, subsequently suppress PC development
    cancerurinary 
    therapeutic target in bladder cancer
    ANIMAL & CELL MODELS