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FLASH GENE
Symbol GPX2 contributors: mct - updated : 30-01-2008
HGNC name glutathione peroxidase 2 (gastrointestinal)
HGNC id 4554
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1024 - 190 - Naiki-Ito (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
 liver    
 stomach   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • glutathione peroxidase involved in free radical detoxification
  • involved in transcriptional response to exogenous redox agents and catabolic pathway of activated oxygen species
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein direct target of TP63, inhibiting oxidative stress-induced apoptosis in a TP53-dependent manner
    cell & other
    REGULATION
    activated by TP63
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS