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FLASH GENE
Symbol RTN1 contributors: mct - updated : 04-06-2015
HGNC name reticulon 1
HGNC id 10467
RNA
TRANSCRIPTS type messenger
text truncated form NSP-B, NSP-C
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3327 83.6 776 small cell lung carcinoma, expressed in neurons of the mammalian central nervous system 2012 2252296
  • NSP-A, or RTN-1A
  • unique N-terminus
  • length of the hydrophobic segment contributes to the ER retention
  • - splicing 2148 38.4 356 NCI-Hg2 cell line 2012 2252296
    unique N terminus
    7 - 1722 - 208 - 2012 2252296
  • NSP-C, or RTN-1C
  • unique N terminus
  • two transmembrane helices and the N- and C-terminal regions which are supposed in the cytosolic side of ER
  • C-terminal region of RTN1-C is characterized by the presence of a H4 histone consensus sequence that makes it able to interact with nucleic acids and HDAC enzymes
  • is able to specifically regulate gene expression, modulating transcript clusters which have been implicated in the onset of neurodegenerative disorders
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Nervousbrain   highly Homo sapiens
     nerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificneuroendocrine cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 200 amino acid C-terminal domain containing two long hydrophobic sequences
  • two transmembrane helices and the N- and C-terminal regions which are supposed in the cytosolic side of ER
  • a C-terminal reticulon homology domain containing two hydrophobic segments and a 66-amino acid hydrophilic loop
  • HOMOLOGY
    Homologene
    FAMILY reticulon family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • anchored to membranes of the endoplasmic reticulum through its carboxy-terminal regions
  • Mutant proteins lacking the first (39 residues) or second (36 residues) hydrophobic segment showed ER localization, but mutant lacking both hydrophobic segments was cytosolic
  • MANF co-localized with RTN1 in the ER
  • basic FUNCTION
  • maybe involved in neuroendocrine secretion and membrane trafficking not inhibiting axonal regeneration
  • RTN1 and RYR2 might act as functional partners in the regulation of cytosolic Ca(2+) dynamics the in neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RYR2 is a direct binding partner of RTN1, and RTN1 and RYR2 might act as functional partners in the regulation of cytosolic Ca(2+) dynamics the in neurons
  • induces PDI redistribution in ER vesicles, and concomitantly modulates its activity by decreasing the levels of its S-nitrosylated form
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    in lung tumor cells, expression of NSP-A and most likely also NSP-C is restricted to cells with a neuroendocrine phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS