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FLASH GENE
Symbol MS4A7 contributors: np/ - updated : 09-03-2007
HGNC name membrane-spanning 4-domains, subfamily A, member 7
HGNC id 13378
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 3024 - 240 - -
6 - 2841 - 195 - -
7 - 2976 - 240 - -
6 - 2889 - 195 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Digestiveintestinelarge intestinecolon  
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/ImmuneB cell
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • transmembrane (TM) protein comprising a short intracellular domain
  • four transmembrane segments (4TM)
  • a long cytoplasmic tail, involved in intracellular signaling, lacking an immunoreceptor tyrosine-based activation motif signal
  • HOMOLOGY
    interspecies homolog to murine Ms4a2
    Homologene
    FAMILY
  • MS4A family (membrane-spanning 4-domains, subfamily A)
  • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in mature cellular function in the monocytic lineage
  • involved in the regulation of B cell activation and proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS