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FLASH GENE

Symbol

A4GALT

contributors: np/ - updated : 29-09-2006

HGNC name	alpha 1,4-galactosyltransferase
HGNC id	18149

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017436 3 - 2106 NP_059132 - 353 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	highly in placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	type II membrane protein
	a short N terminal cytoplasmic sequence
	a transmembrane spanning segment (TM1)
	a large catalytic extracellular domain

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine A4galt

intraspecies

homolog to 4GPcNAc-T(AGLUGT)

Homologene

FAMILY

alpha 1,4-glycosyltransferase family

CATEGORY

enzyme , antigen

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION

catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

synthesis of glycosphingolipids

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PBGS

Susceptibility

Variant & Polymorphism SNP	M183K

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS