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FLASH GENE

Symbol

TEKT3

contributors: mct - updated : 30-11-2010

HGNC name	tektin 3
HGNC id	14293

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031898 8 - 1795 NP_114104 56.6 490 - 1999 10456331

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Homo sapiens Reproductive spermatid Reproductive spermatocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	widely, weak

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a conserved tektin domain

HOMOLOGY

interspecies

homolog to sea urchin tektin A1

Homologene

FAMILY	occludin/ELL family
	tektin family

CATEGORY

motor/contractile , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome

basic FUNCTION	cilia and centriole formation
	microtubule-associated cytoskeletal protein expressed primarily in the male germ cell-lineage in centrioles and basal bodies and within ciliary and flagellar doublet microtubules
	male germ cell-enriched protein that it might perform important roles in male reproductive development and physiology
	important role in male reproductive development and physiology

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	spermatogenesis

PATHWAY

metabolism

signaling

a component

co-assembling with tubulins

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	potential candidate genes for nonsyndromic asthenozoospermia
Marker
Therapy target

ANIMAL & CELL MODELS

	expressed in round spermatids in mouse
	male mice null for TEKT3 produce sperm with reduced motility (47.2p100 motility) and forward progression, and increased flagellar structural bending defects