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FLASH GENE
Symbol TDRD1 contributors: mct - updated : 11-03-2011
HGNC name tudor domain containing 1
HGNC id 11712
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 4510 - 1189 - 2001 11279525
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid Homo sapiens
Reproductivespermatocyte Homo sapiens
Reproductivespermatogonia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region containing the myeloid Nervy DEAF-1 (MYND) domain, for interaction with PIWIL2
  • four tudor domains
  • one KH domain
  • HOMOLOGY
    interspecies ortholog to murine Tdrd1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • present in the cytoplasm of prospermatogonia, spermatocytes, and round spermatids, and predominantly localizes to chromatoid bodies
  • basic FUNCTION
  • binding to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane
  • potentially functions in assembling snRNPs into cytoplasmic granules in germ cells
  • with TDRD6, and RNF17, play evolutionarily conserved roles in germinal granule/nuage formation and germ cell specification and differentiation
  • TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • formation of complexes between PIWIL1, PIWIL2 and TDRD1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis
  • interacting with PIWIL2, that positively regulates the expression of the TDRD1 mRNA
  • TDRD1 is the first identified upregulated direct ERG target gene that is strongly associated with ERG overexpression in primary prostate cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS